Review: statin monotherapy is safe in hyperlipidemia except for increased risk for transaminase elevation.
نویسنده
چکیده
منابع مشابه
Comparison of the safety of statin monotherapy and coadministration with fenofibrate in patients with mixed hyperlipidemia: a meta-analysis
Objective: To compare adverse events of statin monotherapy and combination therapy of statin and fenofibrate. Methods: We searched the online databases of PUBMED and EMBASE for high-quality randomized controlled trials (RCTs). Interested outcomes included discontinuation because of any adverse event, any adverse event, serious adverse events, drug-related adverse events, increase in alanine ami...
متن کاملLetter by Rosenberg and Uretsky regarding article, "Risks associated with statin therapy: a systematic overview of randomized clinical trials".
BACKGROUND Although statins reduce the risk of cardiovascular events, concerns about adverse effects may deter physicians from prescribing these agents. We performed a systematic overview of randomized statin trials to quantify the risks of musculoskeletal, renal, and hepatic complications associated with therapy. METHODS AND RESULTS Major statin trials were identified by electronic search of...
متن کاملRisks Associated With Statin Therapy A Systematic Overview of Randomized Clinical Trials
Background—Although statins reduce the risk of cardiovascular events, concerns about adverse effects may deter physicians from prescribing these agents. We performed a systematic overview of randomized statin trials to quantify the risks of musculoskeletal, renal, and hepatic complications associated with therapy. Methods and Results—Major statin trials were identified by electronic search of t...
متن کاملCholesterol absorption inhibition: filling an unmet need in lipid-lowering management
International guidelines specify target concentrations of low-density lipoprotein cholesterol (LDL-C) to reduce the risk of coronary heart disease. Although statins are the most widely prescribed cholesterol-lowering drugs, they have a number of limitations. A significant number of statin-treated patients do not reach recommended LDL-C target levels, even with high-dose therapy. Each doubling o...
متن کاملEfficacy of Statin Monotherapy or in Combination With Coenzyme A Capsule in Patients With Metabolic Syndrome and Mixed Dyslipidemia
BACKGROUND Patients with metabolic syndrome are at increased risk for cardiovascular disease. Combination lipid-lowering therapy is often needed in patients with metabolic syndrome and mixed dyslipidemia. The aim of this study was to compare the effect of statin combined with a new hypolipidemic agent, coenzyme A (CoA) with moderate-dose statin monotherapy in subjects with metabolic syndrome an...
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ورودعنوان ژورنال:
- ACP journal club
دوره 146 3 شماره
صفحات -
تاریخ انتشار 2007